Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC076
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-20 09:00
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment new patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 32 individuals with a value less than 0.64 were subsequently diagnosed with PD. That is, 76.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.64 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 11, 'TN': 11, 'TP': 31, 'FP': 19}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 23, 'TP': 16, 'FP': 7}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 31, 'TN': 28, 'TP': 11, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 13, 'TN': 9, 'TP': 29, 'FP': 21}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 17.024
timePerCircleCoV 0.0871806
timePerCircleSlope 0.00156642
meanError 1.66814
tremorFreq 6.64062
tremorRelPower 34.0257
tremorGyroAmpMean 0.0155745
tremorGyroAmpSlope 0.000954854
tremorGyroAmpCoV 0.382832
tremorCoordAmpMean 0.0445568
tremorCoordAmpSlope 0.000478443
tremorCoordAmpCoV 0.437347
tremorAccAmpMean 0.0365919
tremorAccAmpSlope 0.000113829
tremorAccAmpCoV 0.347003
tremorPcRelVar 0.597394
tremorPcX -0.5918
tremorPcY 0.806085

Circle Segment 1

Duration 17.72 s, Accuracy Estimate 2.333 (lower is better)

Circle Segment 2

Duration 17.84 s, Accuracy Estimate 1.245 (lower is better)

Circle Segment 3

Duration 15.44 s, Accuracy Estimate 1.411 (lower is better)

Circle Segment 4

Duration 15.4 s, Accuracy Estimate 1.365 (lower is better)

Circle Segment 5

Duration 16.0 s, Accuracy Estimate 1.426 (lower is better)

Circle Segment 6

Duration 18.28 s, Accuracy Estimate 1.316 (lower is better)

Circle Segment 7

Duration 17.28 s, Accuracy Estimate 1.396 (lower is better)

Circle Segment 8

Duration 18.76 s, Accuracy Estimate 1.585 (lower is better)

Circle Segment 9

Duration 18.72 s, Accuracy Estimate 1.637 (lower is better)

Circle Segment 10

Duration 14.8 s, Accuracy Estimate 2.968 (lower is better)

Spiral

numSpirals 6
timePerSpiralMean 51.2733
timePerSpiralCoV 0.0815639
timePerSpiralSlope 0.00394524
meanError 1.74642
tremorFreq 6.54297
tremorRelPower 30.3723
tremorGyroAmpMean 0.013347
tremorGyroAmpSlope -0.000298085
tremorGyroAmpCoV 0.409278
tremorCoordAmpMean 0.0397832
tremorCoordAmpSlope -0.000253048
tremorCoordAmpCoV 0.302973
tremorAccAmpMean 0.0336618
tremorAccAmpSlope -0.000575812
tremorAccAmpCoV 0.355279
tremorPcRelVar 0.727744
tremorPcX -0.808671
tremorPcY 0.588261

Spiral Segment 1

Duration 56.88 s, Accuracy Estimate 1.592 (lower is better)

Spiral Segment 2

Duration 45.36 s, Accuracy Estimate 1.655 (lower is better)

Spiral Segment 3

Duration 50.28 s, Accuracy Estimate 1.76 (lower is better)

Spiral Segment 4

Duration 48.52 s, Accuracy Estimate 1.746 (lower is better)

Spiral Segment 5

Duration 51.84 s, Accuracy Estimate 1.552 (lower is better)

Spiral Segment 6

Duration 54.76 s, Accuracy Estimate 2.173 (lower is better)

Elel

eDurationMean 0.882273
eDurationStd 0.127089
eDurationStdnorm 0.144048
eDurationMedian 0.895
eDurationQuartdelta 0.17375
eDurationQuartdeltanorm 0.194134
eDurationKurt 3.01561
eDurationTrenddiff -0.1
eDurationTrendratio 0.891892
eWidthMean 3.63055
eWidthStd 1.13303
eWidthStdnorm 0.312083
eWidthMedian 3.276
eWidthQuartdelta 1.053
eWidthQuartdeltanorm 0.321429
eWidthKurt 3.64194
eWidthTrenddiff 0.5265
eWidthTrendratio 1.17308
eHeightMean 6.78245
eHeightStd 1.91503
eHeightStdnorm 0.282351
eHeightMedian 6.435
eHeightQuartdelta 1.521
eHeightQuartdeltanorm 0.236364
eHeightKurt 13.1509
eHeightTrenddiff -0.1755
eHeightTrendratio 0.973214
eAspectMean 0.55061
eAspectStd 0.171154
eAspectStdnorm 0.310845
eAspectMedian 0.522727
eAspectQuartdelta 0.178675
eAspectQuartdeltanorm 0.341813
eAspectKurt 6.51401
eAspectTrenddiff 0.0237446
eAspectTrendratio 1.04592
eSlantMean -0.0190001
eSlantStd 0.143996
eSlantStdnorm -7.5787
eSlantMedian -0.0181818
eSlantQuartdelta 0.157858
eSlantQuartdeltanorm -8.6822
eSlantKurt 3.29207
eSlantTrenddiff 0.0043771
eRtopMean 0.628311
eRtopStd 0.158678
eRtopStdnorm 0.252548
eRtopMedian 0.641026
eRtopQuartdelta 0.160033
eRtopQuartdeltanorm 0.249651
eRtopKurt 3.37652
eRtopTrenddiff -0.067979
eRbotMean 0.701519
eRbotStd 0.247306
eRbotStdnorm 0.35253
eRbotMedian 0.65625
eRbotQuartdelta 0.267859
eRbotQuartdeltanorm 0.408166
eRbotKurt 7.39863
eRbotTrenddiff -0.0479693
eRrightMean 0.780277
eRrightStd 0.0928041
eRrightStdnorm 0.118937
eRrightMedian 0.795455
eRrightQuartdelta 0.120393
eRrightQuartdeltanorm 0.151351
eRrightKurt 3.18837
eRrightTrenddiff -0.0428472
eRleftMean 0.425225
eRleftStd 0.17357
eRleftStdnorm 0.408183
eRleftMedian 0.44
eRleftQuartdelta 0.191475
eRleftQuartdeltanorm 0.435171
eRleftKurt 3.13491
eRleftTrenddiff -0.0491189
lDurationMean 1.25118
lDurationStd 0.182392
lDurationStdnorm 0.145776
lDurationMedian 1.195
lDurationQuartdelta 0.275
lDurationQuartdeltanorm 0.230126
lDurationKurt 2.0154
lDurationTrenddiff -0.025
lDurationTrendratio 0.979167
lWidthMean 5.72612
lWidthStd 1.02766
lWidthStdnorm 0.179468
lWidthMedian 5.616
lWidthQuartdelta 1.521
lWidthQuartdeltanorm 0.270833
lWidthKurt 2.61045
lWidthTrenddiff 0
lWidthTrendratio 1
lHeightMean 14.7764
lHeightStd 2.18043
lHeightStdnorm 0.147561
lHeightMedian 14.391
lHeightQuartdelta 3.393
lHeightQuartdeltanorm 0.235772
lHeightKurt 2.34172
lHeightTrenddiff -0.117
lHeightTrendratio 0.991935
lAspectMean 0.38925
lAspectStd 0.0554212
lAspectStdnorm 0.14238
lAspectMedian 0.376753
lAspectQuartdelta 0.0692614
lAspectQuartdeltanorm 0.183838
lAspectKurt 3.60991
lAspectTrenddiff 0.0012117
lAspectTrendratio 1.00322
lSlantMean 0.0751488
lSlantStd 0.112882
lSlantStdnorm 1.50211
lSlantMedian 0.0895603
lSlantQuartdelta 0.161491
lSlantQuartdeltanorm 1.80315
lSlantKurt 2.47371
lSlantTrenddiff -0.0856209
lRtopMean 0.736777
lRtopStd 0.10159
lRtopStdnorm 0.137884
lRtopMedian 0.75
lRtopQuartdelta 0.161754
lRtopQuartdeltanorm 0.215671
lRtopKurt 2.29109
lRtopTrenddiff -0.111826
lRbotMean 0.562059
lRbotStd 0.209764
lRbotStdnorm 0.373206
lRbotMedian 0.5
lRbotQuartdelta 0.274468
lRbotQuartdeltanorm 0.548936
lRbotKurt 2.3853
lRbotTrenddiff 0.131845
lRrightMean 0.879997
lRrightStd 0.0629713
lRrightStdnorm 0.0715585
lRrightMedian 0.87847
lRrightQuartdelta 0.074812
lRrightQuartdeltanorm 0.0851617
lRrightKurt 3.12686
lRrightTrenddiff -0.0599169
lRleftMean 0.344066
lRleftStd 0.119436
lRleftStdnorm 0.347132
lRleftMedian 0.331845
lRleftQuartdelta 0.182287
lRleftQuartdeltanorm 0.549312
lRleftKurt 2.31901
lRleftTrenddiff 0.00414079

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

FITTS Short Modified

meanTouchScore 0.886951
sumTouchScores 14.1912
meanMovementTime 1.117
numTouches 16
undershootPercentage 0
overshootPercentage 18.75

FITTS Long Modified

meanTouchScore 0.923077
sumTouchScores 12
meanMovementTime 1.53
numTouches 13
undershootPercentage 7.69231
overshootPercentage 0

ZigZag

numZigzags 5
timePerZigzagMean 48.544
timePerZigzagCoV 0.0658696
timePerZigzagSlope 0.0374094
meanError 1.99364
tremorFreq 6.15234
tremorRelPower 28.9468
tremorGyroAmpMean 0.0143667
tremorGyroAmpSlope -0.000646021
tremorGyroAmpCoV 0.355341
tremorCoordAmpMean 0.0573787
tremorCoordAmpSlope -0.000948153
tremorCoordAmpCoV 1.57229
tremorAccAmpMean 0.0793187
tremorAccAmpSlope -0.000247793
tremorAccAmpCoV 0.116013
tremorPcRelVar 0.79575
tremorPcX -0.132149
tremorPcY -0.99123

ZigZag Segment 1

Duration 45.96 s, Accuracy Estimate 2.08 (lower is better)

ZigZag Segment 2

Duration 45.6 s, Accuracy Estimate 1.99 (lower is better)

ZigZag Segment 3

Duration 47.2 s, Accuracy Estimate 1.902 (lower is better)

ZigZag Segment 4

Duration 52.24 s, Accuracy Estimate 1.799 (lower is better)

ZigZag Segment 5

Duration 51.72 s, Accuracy Estimate 2.197 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 23.624
timePerZigzagCoV 0.15527
timePerZigzagSlope -0.0728073
zigzagHeightMean 51.9018
zigzagHeightCoV 0.0719077
zigzagHeightSlope -0.0177189
meanError 0.0348827
tremorFreq 6.54297
tremorRelPower 39.5267
tremorGyroAmpMean 0.0176559
tremorGyroAmpSlope -0.00156251
tremorGyroAmpCoV 0.367696
tremorCoordAmpMean 0.0540944
tremorCoordAmpSlope -0.000307534
tremorCoordAmpCoV 0.378667
tremorAccAmpMean 0.0434335
tremorAccAmpSlope -0.00168933
tremorAccAmpCoV 0.477697
tremorPcRelVar 0.624941
tremorPcX 0.511127
tremorPcY -0.859505

ZigZag Offset Segment 1

Duration 29.44 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 2

Duration 22.28 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 3

Duration 22.16 s, Accuracy Estimate 0.024 (lower is better)

ZigZag Offset Segment 4

Duration 24.52 s, Accuracy Estimate 0.021 (lower is better)

ZigZag Offset Segment 5

Duration 19.72 s, Accuracy Estimate 0.046 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.72}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.64}
BM_May22 {‘BM_May22_class’: ‘NOT PD’, ‘BM_May22_score’: 0.9468101433702194}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9028249735980876}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8051434268844943}